Antioquia Commences Further Drilling and Geophysics at the Cisneros Project in Colombia 27/09/2010

September 27, 2010, Calgary, Alberta: Antioquia Gold Inc. (TSX-V: AGD) Antioquia is pleased to announce continued success of the drilling program and the latest drill results from the 5 hereto unreported holes on its Guayabito Prospect at the Cisneros Gold project in Colombia (PC10-33 through PC10-37). Additional sampling is continuing to further define the rock characteristics adjacent to the main mineralized structures needed to define resource calculations and mine design parameters. Figure 1 shows the location of all the prospects drilled to date on the Cisneros Project.

Results of this report continue to demonstrate zones of very high grade gold mineralization in the Guayabito area and augment those previously reported in press releases from (December 21, 2009, January 25, 2010, June 14, 2010 and August 9, 2010). Highlights of this report include drill hole PC10-35 encountering 0.5 meters at 140.4 g/t gold and PC10-37 encountering 1.3 meters at 22.6 g/t gold. Table 1 shows significant intersections and gold values from the latest drill program.

Drilling and geological modeling to date has identified a series of parallel structures on the Guayabito prospect area containing high grade mineralization in a plane oriented (striking) approximately north south and vertical. Two of these structures (Bolo and Guayabito) have been traced over approximately 150m along strike to the north and to a depth of 250m on the property. Figure 2 shows the surface trace of the Bolo and Guayabito structures, which are open to depth and to the north. As previously reported these structures are dominated by mineralization consisting of quartz and sulphides (chalcopyrite, and pyrite). Gold is closely associated with sulphides and quartz.

Logan Drilling has been contracted to complete the remaining footage of the previously announced 10,000m drilling program for 2010. The drilling will focus on defining the Bolo and Guayabito structures to the north and to depth. Figure 3 is a longitudinal section on the Bolo structure showing where existing drill holes intersect, and proposed drill holes are anticipated to intersect, the structure. Details of these intersections can be found on the website at www.antioquiagoldinc.com.

Drilling has continued to validate the model and structural interpretation provided by Bob Casaceli. He suggests that the east-west driving structures have acted as left-lateral strike-slip faults that have locally created en echelon dilational jogs with maximum extension having been developed along secondary north-south faults, such as the structures currently being drilled at Guayabito, where attendant low-pressure zones favored fluid injection and subsequent gold deposition. This interpretation explains why higher gold grades at Cisneros tend to occur along north-south faults, and along east-west faults near intersections with north-south faults.

Antioquia Gold Inc.

Antioquia is a Calgary-based mineral exploration company, focused on searching out precious metals and other opportunities in Colombia. The Company’s flagship property is the Cisneros project, located 70 kilometres northeast of Medellin in the Department of Antioquia in Colombia.

This press release has been prepared under the supervision of Brad Van Den Bussche, P. Geol., Vice President of Exploration for Antioquia Gold Inc. and a Qualified Person as defined by National Instrument 43-101.

To ensure reliable sample results Antioquia has a rigorous QA/QC program in place that monitors the chain of custody of the samples and includes the insertion of blanks, preparation duplicates, field duplicates, and certified reference standards in each batch of samples. Core is photographed and sawed in half with one half retained in a secured facility for future reference if needed. Sample preparation (crushing and pulverizing) is performed at SGS laboratories in Medellin, Colombia.

Prepared samples are direct-shipped to SGS Laboratories in Lima, Peru, an ISO certified laboratory, for analysis. Assay for gold is performed by fire assay with 30 g charge and AAS finish, with a gravimetric finish for over limit samples.

Caution regarding forward-looking information:

This press release may contain forward-looking statements. Such forward-looking statements involve a number of known and unknown risks, uncertainties and other factors which may cause the actual results, performance or achievements of Antioquia Gold Inc. to be materially different from actual future results and achievements expressed or implied by such forward-looking statements. Actual results can differ materially from those anticipated by management at the time of writing due to many factors, the majority of which are beyond the control of Antioquia Gold Inc. and its management. Readers are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date the statements were made. Readers are also advised to consider such forward-looking statements while considering the risks involved.

For further information on Antioquia Gold Inc., visit our website at
www.antioquiagoldinc.com or contact,

Sheri Torske, Manager, Investor Relations
(403) 260-5383
Email: storske@antioquiagoldinc.com

Rick Thibault, President & CEO
(484) 319-7807
Email: rthibault@antioquiagoldinc.com

Neither the TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.